L'article: "It remains unclear how the specific subclass kinetics with delayed IgG2 and IgG4 induction by mRNA vaccination, here first described in children, affects long-term immunity. A study by de Jong et al performed immunophenotyping and sequencing of peripheral blood mononuclear cells from young children and adults to investigate sequential IgG subclass switching. Their findings suggest that an accumulation of specific IgG2- and IgG4-expressing memory B cells occurs with age, is associated with increasing levels of somatic hypermutation and might represent a marker for an efficient generation of memory responses.9 We hope that our observation will stimulate more studies on both similarities and differences of immune responses in adults and children, for example, regarding switching of IgG subclasses and functionality of vaccine-induced antibodies.'

L'OP: " OH MON DIEU CA ALTERE LA REPONSE IMMUNITAIRE "